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Entry M0192    5.3.99.3    prostaglandin-E synthase

Previous Step

Step 04

The thiolate of Cts110 deprotonates water in an inferred return step.

This reaction step has been inferred

GIF of Reaction Step M0192.stg04



Mechanisms

Proton Transfer

Mechanism Components

Bond Formation
Bond Cleavage
Intermediate Terminated
Enzyme Regenerated

Amino acids involved in the reaction step.

Amino Acid Location of Function Activity Function
Tyr107A Side Chain spectator Hydrogen Bond Donor
Activator
Tyr107A Main Chain Amide spectator Hydrogen Bond Donor
Cys113 Side Chain spectator Hydrogen Bond Donor
Hydrogen Bond Acceptor
Electrostatic Stabiliser
Cys110 Side Chain reactant Hydrogen Bond Acceptor
Proton Acceptor
Phe112 Main Chain Amide spectator Hydrogen Bond Donor
Electrostatic Stabiliser

Reactive Centre

Bonds Formed Bonds Cleaved Bonds Changed in Order Atom Types Involved
S-H
O-H
None
H
O
S

View similar reactions in MACiE.


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