Entry M0192 18.104.22.168 prostaglandin-E synthase
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A hydroxide ion deprotonates the C9 of the covalently bound intermediate initiating an elimination reaction that releases the thiolate form of Cys110 and the prostaglandin E2 product
Comment: An R-SH (or a water) bound between OH of Tyr107 and C9 of PGH2 is polarised by forming a H-bond with Tyr107, and consequently, the thiol group of R-SH (or water) is deprotonated at neutral pH. The resulting thiolic anion (or hydroxyl anion) removes the hydrogen atom attached to C9 .
Amino acids involved in the reaction step.
||Bonds Changed in Order
||Atom Types Involved
The C-O bond changes from a single to double bond
View similar reactions in MACiE.