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Entry M0169    3.4.14.5    dipeptidyl-peptidase IV

Next Step

Step 01

His740 in a Ser-His-Asp triad deprotonates Ser630.

GIF of Reaction Step M0169.stg01



Mechanisms

Proton Transfer

Mechanism Components

Bond Formation
Bond Cleavage

Amino acids involved in the reaction step.

Amino Acid Location of Function Activity Function
Asp708 Side Chain spectator Hydrogen Bond Acceptor
Activator
His740 Side Chain reactant Hydrogen Bond Acceptor
Hydrogen Bond Donor
Proton Acceptor
Ser630 Side Chain reactant Hydrogen Bond Donor
Proton Donor
Tyr631 Main Chain Amide spectator Hydrogen Bond Donor
Tyr547 Side Chain spectator Hydrogen Bond Donor

Reactive Centre

Bonds Formed Bonds Cleaved Bonds Changed in Order Atom Types Involved
N-H
O-H
None
H
N
O

View similar reactions in MACiE.


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