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Entry M0156    2.8.4.1    coenzyme-B sulfoethylthiotransferase

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Step 04

The thiolate of coenzyme B attacks the thiyl radical of coenzyme M in a coordination reaction.

GIF of Reaction Step M0156.stg04



Mechanisms

Coordination
Radical Propagation

Mechanism Components

Bond Formation
Intermediate Formation

Amino acids involved in the reaction step.

Amino Acid Location of Function Activity Function
Tyr367E Side Chain spectator Electrostatic Stabiliser
Gln147 Side Chain spectator Electrostatic Stabiliser
Metal Ligand

Organic Cofactors involved in the reaction step

Cofactor Type Cofactor Activity Function
Coenzyme B TP79000 reactant Nucleophile
Hydrogen Bond Acceptor
Coenzyme M COM9700 reactant Electrophile

Metal Cofactors involved in Step 04

Metal Type Metal Identity Chain Activity Function
nickel F43 700 x spectator Not Active

Reactive Centre

Bonds Formed Bonds Cleaved Bonds Changed in Order Atom Types Involved
S-S
None
None
S

View similar reactions in MACiE.


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