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Entry M0156    2.8.4.1    coenzyme-B sulfoethylthiotransferase

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Step 02

Tyr367E deprotonates coenzyme M, causing it to donate a single electron to the Ni(III) ion of factor 430.

GIF of Reaction Step M0156.stg02


Comment: We assume Tyr367E acts as a proton acceptor in this step.



Mechanisms

Proton Transfer
Redox
Radical Formation

Mechanism Components

Bond Cleavage
Bond Formation
Intermediate Formation

Amino acids involved in the reaction step.

Amino Acid Location of Function Activity Function
Tyr367E Side Chain reactant Hydrogen Bond Acceptor
Proton Acceptor
Gln147 Side Chain spectator Electrostatic Stabiliser
Metal Ligand

Organic Cofactors involved in the reaction step

Cofactor Type Cofactor Activity Function
Coenzyme B TP79000 spectator Hydrogen Bond Donor
Coenzyme M COM9700 reactant Proton Donor
Hydrogen Bond Donor
One Electron Donor

Metal Cofactors involved in Step 02

Metal Type Metal Identity Chain Activity Function
nickel F43 700 x reactant Substrate Binding
One Electron Acceptor

Reactive Centre

Bonds Formed Bonds Cleaved Bonds Changed in Order Atom Types Involved
O-H
S-H
None
H
O
S

View similar reactions in MACiE.


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