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Entry M0152    2.7.8.7    holo-[acyl-carrier-protein] synthase

Next Step

Step 01

Magnesium activated water deprotonates the Apo-ACP, activating it.

GIF of Reaction Step M0152.stg01


Comment: Here, the first base depicted as a water molecule could also correspond to Asp35 of the acyl-carrier protein (ACP).



Mechanisms

Proton Transfer

Mechanism Components

Overall Reactant Used
Bond Formation
Bond Cleavage
Intermediate Formation
Proton Relay

Amino acids involved in the reaction step.

Amino Acid Location of Function Activity Function
His105 Main Chain Amide spectator Hydrogen Bond Donor
Electrostatic Stabiliser
Lys62B Side Chain spectator Hydrogen Bond Donor
Electrostatic Stabiliser

Metal Cofactors involved in Step 01

Metal Type Metal Identity Chain Activity Function
magnesium CA 130 A spectator Substrate Binding
Activator
Increase Acidity

Reactive Centre

Bonds Formed Bonds Cleaved Bonds Changed in Order Atom Types Involved
O-H
O-H
O-H
O-H
None
H
O

View similar reactions in MACiE.


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