Entry M0146 184.108.40.206 pyrogallol hydroxytransferase
His144 deprotonates the pyrogallol substrate at the C3-OH position, the activated substrate then attacks the molybdenum cofactor in a nucleophilic substitution, resulting in the loss of a water molecule from the Mo(VI) coordination sphere.
Comment: Molybdenum (Mo(VI)) is coordinated to four sulfur ligands from both molybdopterin guanine dinucleotides, OG from Ser175A and a hydroxyl or water molecule .
Amino acids involved in the reaction step.
Metal Cofactors involved in Step 01
||Bonds Changed in Order
||Atom Types Involved
View similar reactions in MACiE.