Entry M0144 18.104.22.168 arsenite oxidase
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An unidentified base activates water to attack the Mo(IV), forming a hydroxide group in place of the lost oxo group in a nucleophilic addition to the Mo(IV).
Comment: The most likely explanation for the transfer of two protons upon electrochemical oxidation without the presence of a pK transition over the range of pH 5-10 is that they are derived from an uncoordinated water in the Mo(IV) state, leaving an unprotonated oxo in the Mo(VI) state . There is also evidence that under single-turnover conditions in [18-O] water, 18-O is incorporated into the molybdenum centre as a terminal oxo (Mo=O) group .
Amino acids involved in the reaction step.
Organic Cofactors involved in the reaction step
|Molybdopterin guanosine dinucleotide
Metal Cofactors involved in Step 03
||Bonds Changed in Order
||Atom Types Involved
The Mo-O bond changes from a triple to double bond
View similar reactions in MACiE.