Entry M0143 18.104.22.168 arsenate reductase
Previous Step Next Step
Thiolate of Cys82 attacks the sulfur of Cys10 in a nucleophilic substitution reaction that releases the arsenite product, and creates a disulfide bond between Cys10 and Cys82.
Comment: The formation of the Cys10-Cys82 disulfide bond triggers the structural change that allows Cys89 to move out of its hydrophobic core, so that it can attack Cys82 .
Amino acids involved in the reaction step.
Metal Cofactors involved in Step 02
||Bonds Changed in Order
||Atom Types Involved
The As-O bond changes from a double to single bond
View similar reactions in MACiE.