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Entry M0133    1.14.15.1    camphor 5-monooxygenase

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Step 02

In a homolytic addition, Fe(II) donates a single electron to the dioxygen substrate.

GIF of Reaction Step M0133.stg02



Mechanisms

Bimolecular Homolytic Addition
Redox
Radical Formation

Mechanism Components

Overall Reactant Used
Bond Formation
Metal Coordination
Bond Order Change
Intermediate Formation

Amino acids involved in the reaction step.

Amino Acid Location of Function Activity Function
Arg186 Side Chain spectator Hydrogen Bond Donor
Asp251 Side Chain spectator Hydrogen Bond Donor
Hydrogen Bond Acceptor
Thr252 Side Chain spectator Hydrogen Bond Acceptor
Hydrogen Bond Donor
Cys357 Side Chain spectator Metal Ligand
Electrostatic Stabiliser
Hydrogen Bond Acceptor
Leu358 Main Chain Amide spectator Hydrogen Bond Donor
Electrostatic Stabiliser
Gly359 Main Chain Amide spectator Hydrogen Bond Donor
Electrostatic Stabiliser

Metal Cofactors involved in Step 02

Metal Type Metal Identity Chain Activity Function
iron HEM 417 A reactant Substrate Binding
One Electron Donor
Activator

Reactive Centre

Bonds Formed Bonds Cleaved Bonds Changed in Order Atom Types Involved
Fe-O
None
The O-O bond changes from a double to single bond
Fe
O

View similar reactions in MACiE.


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