spacer

Entry M0130    1.14.12.12    naphthalene 1,2-dioxygenase

Previous Step     Next Step

Step 05

The epoxide intermediate collapses in a heterolysis resulting in a carbocation and anioinc oxygen bound to the Fe(III) centre.

GIF of Reaction Step M0130.stg05



Mechanisms

Heterolysis

Mechanism Components

Bond Cleavage
Intermediate Formation

Amino acids involved in the reaction step.

Amino Acid Location of Function Activity Function
His104 Side Chain spectator Metal Ligand
Hydrogen Bond Donor
Asp205E Side Chain spectator Hydrogen Bond Acceptor
His208E Side Chain spectator Metal Ligand
Hydrogen Bond Donor

Organic Cofactors involved in the reaction step

Cofactor Type Cofactor Activity Function
FAD FAD spectator Not Active

Metal Cofactors involved in Step 05

Metal Type Metal Identity Chain Activity Function
iron FES 451 A spectator Not Active
iron FE 452 A spectator Substrate Binding
iron FE(not in PDB) 1 x spectator Not Present
iron FE(not in PDB) 2 x spectator Not Present

Reactive Centre

Bonds Formed Bonds Cleaved Bonds Changed in Order Atom Types Involved
None
C-O
None
C
O

View similar reactions in MACiE.


spacer
spacer