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Entry M0125    1.10.3.1    catechol oxidase

Next Step

Step 01

The bridging hydroxide deprotonates the benzene-1,2-diol, which initiates a nucleophilic attack on the Cu(I) centre, initiating a single electron transfer to dioxygen. The dioxygen radical then replaces the water as the bridging ligand between the two copper centres.

GIF of Reaction Step M0125.stg01



Mechanisms

Proton Transfer
Bimolecular Nucleophilic Substitution
Redox
Bimolecular Homolytic Addition
Radical Formation

Mechanism Components

Overall Reactant Used
Bond Formation
Metal Coordination
Cofactor Used
Bond Cleavage
Metal De-coordination
Bond Order Change
Intermediate Formation
Overall Product Formed

Amino acids involved in the reaction step.

Amino Acid Location of Function Activity Function
Phe261 Side Chain spectator Polar Non-polar interaction
Steric Role

Metal Cofactors involved in Step 01

Metal Type Metal Identity Chain Activity Function
copper C2O 500 A spectator Substrate Binding
Activator
copper C2O 500 A reactant Substrate Binding
Activator
One Electron Donor

Reactive Centre

Bonds Formed Bonds Cleaved Bonds Changed in Order Atom Types Involved
Cu-O
Cu-O
Cu-O
O-H
Cu-O
Cu-O
O-H
The O-O bond changes from a double to single bond
Cu
H
O

View similar reactions in MACiE.


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