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Entry M0122    1.8.4.11    protein-methionine-S-oxide reductase

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Step 04

Cys227 initiates a nucleophilic attack on Cys218 in a substitution reaction, eliminating Cys72.

GIF of Reaction Step M0122.stg04



Mechanisms

Bimolecular Nucleophilic Substitution

Mechanism Components

Bond Formation
Bond Cleavage

Amino acids involved in the reaction step.

Amino Acid Location of Function Activity Function
Tyr155 Side Chain spectator Not Active
Glu115 Side Chain spectator Not Active
Tyr103 Side Chain spectator Not Active
Cys72 Side Chain reactant Nucleofuge
Cys218 Side Chain reactant Electrophile
Electrofuge
Cys227 Side Chain reactant Nucleophile

Reactive Centre

Bonds Formed Bonds Cleaved Bonds Changed in Order Atom Types Involved
S-S
S-S
None
S

View similar reactions in MACiE.


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