Entry M0111    glutamate synthase (ferredoxin)

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Step 09

Ferredoxin donates a single electron, which is transferred to FMN through an iron-sulfur cluster. FMN deprotonates water.

GIF of Reaction Step M0111.stg09

Comment: This reaction occurs in the FMN-binding domain (CATH code The general base in this reaction is assumed to be water due to there being no suitable residues in close proximity (from examination of the PDB file) to the N5 of FMN.


Proton Transfer
Radical Formation

Mechanism Components

Overall Reactant Used
Bond Formation
Bond Cleavage
Bond Order Change
Intermediate Formation
Overall Product Formed
Electron Relay

Amino acids involved in the reaction step.

Amino Acid Location of Function Activity Function
Gln969 Side Chain spectator Not Active
Gln978 Main Chain Amide spectator Not Active
Lys972 Side Chain spectator Not Active
Glu903 Side Chain spectator Not Active

Organic Cofactors involved in the reaction step

Cofactor Type Cofactor Activity Function
FMN FMN2508 reactant Hydrogen Bond Acceptor
Hydrogen Bond Donor
Proton Acceptor
One Electron Acceptor

Metal Cofactors involved in Step 09

Metal Type Metal Identity Chain Activity Function
iron F3S 2509 A reactant Electron Relay
One Electron Acceptor
One Electron Donor

Reactive Centre

Bonds Formed Bonds Cleaved Bonds Changed in Order Atom Types Involved
The C-N bond changes from a double to single bond

View similar reactions in MACiE.