Entry M0107 126.96.36.199 carbon-monoxide dehydrogenase (acceptor)
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The sulfur dianion bridging the Mo(IV) and Cu(I) centres initiates a nucleophilic attack on the carbocation in a substitution reaction that displaces the carbon from the Cu(I) centre.
Comment: Upon inhibition with n-butylisocyanide (which mimics the product state of this step), the enzyme is Mo-EPR and Cu-EPR silent from temperatures of 16 to 120 K, suggesting that the oxidation states are +IV and +I respectively. These oxidation states are further supported by the shapes of the Mo- and Cu-K edges of the inactivated enzyme revealed by X-ray absorption spectroscopy .
Amino acids involved in the reaction step.
Organic Cofactors involved in the reaction step
Metal Cofactors involved in Step 03
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