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Entry M0107    1.2.99.2    carbon-monoxide dehydrogenase (acceptor)

Next Step

Step 01

Carbon monoxide coordinates to the Cu(I) centre.

GIF of Reaction Step M0107.stg01


Comment: The interaction of the SG of Cys388 with the Cu establishes a tensed conformational state of the oxidised cluster [1].



Mechanisms

Coordination

Mechanism Components

Overall Reactant Used
Bond Formation
Metal Coordination
Cofactor Used
Intermediate Formation

Amino acids involved in the reaction step.

Amino Acid Location of Function Activity Function
Glu763 Side Chain spectator Not Active
Cys388 Side Chain spectator Metal Ligand
Electrostatic Stabiliser
Steric Role

Organic Cofactors involved in the reaction step

Cofactor Type Cofactor Activity Function
FAD FAD3932 spectator Not Active

Metal Cofactors involved in Step 01

Metal Type Metal Identity Chain Activity Function
iron FES 3907 x spectator Not Active
iron FES 3908 x spectator Not Active
copper CUB 3921 x spectator Substrate Binding
molybdenum CUB 3921 x spectator Substrate Binding

Reactive Centre

Bonds Formed Bonds Cleaved Bonds Changed in Order Atom Types Involved
Cu-C
None
None
C
Cu

View similar reactions in MACiE.


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