spacer

Entry M0105    1.2.3.1    aldehyde oxidase

Previous Step     Next Step

Step 02

Water deprotonates Glu869, which initiates a nucleophilic attack on the Mo(IV) centre, displacing the carboxylic acid product in a substitution reaction.

GIF of Reaction Step M0105.stg02



Mechanisms

Proton Transfer
Acidic Bimolecular Nucleophilic Substitution

Mechanism Components

Bond Formation
Bond Cleavage
Intermediate Collapse
Intermediate Formation
Overall Product Formed
Metal Coordination
Metal De-coordination

Amino acids involved in the reaction step.

Amino Acid Location of Function Activity Function
Glu869 Side Chain reactant Proton Donor
Hydrogen Bond Donor
Nucleophile

Metal Cofactors involved in Step 02

Metal Type Metal Identity Chain Activity Function
iron FES 908 x spectator Not Active
iron FES 909 x spectator Not Active
molybdenum PCD 921 x spectator Substrate Binding

Reactive Centre

Bonds Formed Bonds Cleaved Bonds Changed in Order Atom Types Involved
Mo-O
O-H
Mo-O
O-H
None
H
Mo
O

View similar reactions in MACiE.


spacer
spacer