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Entry M0104    1.1.5.2    quinoprotein glucose dehydrogenase

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Step 02

The C5-oxyanion deprotonated His144.

GIF of Reaction Step M0104.stg02



Mechanisms

Proton Transfer

Mechanism Components

Bond Formation
Bond Cleavage
Intermediate Formation

Amino acids involved in the reaction step.

Amino Acid Location of Function Activity Function
His144 Side Chain reactant Proton Donor
Hydrogen Bond Donor
Asp163 Side Chain spectator Hydrogen Bond Acceptor
Electrostatic Stabiliser
Arg228 Side Chain spectator Hydrogen Bond Donor
Electrostatic Stabiliser

Organic Cofactors involved in the reaction step

Cofactor Type Cofactor Activity Function
PQQ PQQ1 reactant Hydrogen Bond Acceptor
Proton Acceptor
Metal Ligand

Metal Cofactors involved in Step 02

Metal Type Metal Identity Chain Activity Function
calcium CA 1003 A spectator Cofactor Binding
Electrostatic Stabiliser

Reactive Centre

Bonds Formed Bonds Cleaved Bonds Changed in Order Atom Types Involved
O-H
N-H
None
H
N
O

View similar reactions in MACiE.


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