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Entry M0102    1.1.2.3    L-lactate dehydrogenase (cytochrome)

Previous Step

Step 06

Water deprotonates His373 in an inferred return step.

This reaction step has been inferred

GIF of Reaction Step M0102.stg06



Mechanisms

Proton Transfer

Mechanism Components

Bond Cleavage
Bond Formation
Enzyme Regenerated
Overall Product Formed

Amino acids involved in the reaction step.

Amino Acid Location of Function Activity Function
Tyr254 Side Chain spectator Hydrogen Bond Donor
Asp282 Side Chain spectator Hydrogen Bond Acceptor
Electrostatic Stabiliser
His373 Side Chain reactant Hydrogen Bond Donor
Proton Donor

Organic Cofactors involved in the reaction step

Cofactor Type Cofactor Activity Function
FMN FMN570 spectator Not Active

Metal Cofactors involved in Step 06

Metal Type Metal Identity Chain Activity Function
iron HEM 560 A spectator Not Active

Reactive Centre

Bonds Formed Bonds Cleaved Bonds Changed in Order Atom Types Involved
O-H
N-H
None
H
N
O

View similar reactions in MACiE.


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