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Entry M0102    1.1.2.3    L-lactate dehydrogenase (cytochrome)

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Step 02

A single electron is transferred from the FAD to the haem cofactor.

GIF of Reaction Step M0102.stg02



Mechanisms

Redox
Radical Formation

Mechanism Components

Cofactor Used
Bond Order Change
Intermediate Formation

Amino acids involved in the reaction step.

Amino Acid Location of Function Activity Function
Tyr254 Side Chain spectator Not Active
Asp282 Side Chain spectator Hydrogen Bond Acceptor
Electrostatic Stabiliser
His373 Side Chain spectator Hydrogen Bond Donor

Organic Cofactors involved in the reaction step

Cofactor Type Cofactor Activity Function
FMN FMN570 reactant One Electron Donor

Metal Cofactors involved in Step 02

Metal Type Metal Identity Chain Activity Function
iron HEM 560 A reactant One Electron Acceptor

Reactive Centre

Bonds Formed Bonds Cleaved Bonds Changed in Order Atom Types Involved
None
None
The C-N bond changes from a single to double bond
The C-C bond changes from a double to single bond
C
N

View similar reactions in MACiE.


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