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Entry M0092    1.1.1.22    UDP-glucose 6-dehydrogenase

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Step 02

Cys260 initiates a nucleophilic attack on the formed carbonyl carbon in an addition reaction.

GIF of Reaction Step M0092.stg02



Mechanisms

Bimolecular Nucleophilic Addition

Mechanism Components

Bond Formation
Bond Order Change
Enzyme-Substrate Bond Formation
Intermediate Formation

Amino acids involved in the reaction step.

Amino Acid Location of Function Activity Function
Thr118 Side Chain spectator Hydrogen Bond Acceptor
Asp264 Side Chain spectator Hydrogen Bond Donor
Lys204 Side Chain spectator Hydrogen Bond Donor
Electrostatic Stabiliser
Asn208 Side Chain spectator Hydrogen Bond Donor
Electrostatic Stabiliser
Glu145 Side Chain spectator Hydrogen Bond Acceptor
Cys260 Side Chain reactant Nucleophile

Reactive Centre

Bonds Formed Bonds Cleaved Bonds Changed in Order Atom Types Involved
C-S
None
The C-O bond changes from a double to single bond
C
O
S

View similar reactions in MACiE.


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