Overview for MACiE Entry M0079
EC Number: 126.96.36.199 (A member of the Transferases, Glycosyltransferases, Pentosyltransferases)
Enzyme Name: nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase
Biological Species: Salmonella typhimurium (Bacteria)
Catalytic Chain UniprotKB Accession Codes:
- Q05603 - Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase
Representative PDB Code: 1d0s - CRYSTAL STRUCTURE OF NICOTINATE MONONUCLEOTIDE : 5,6-DIMETHYLBENZIMIDAZOLE PHOSPHORIBOSYLTRANSFERASE (COBT) FROMSALMONELLA TYPHIMURIUM COMPLEXED WITH 5, 6-DIMETHYLBENZIMIDAZOLE (Resolution = 1.90 Å).
Catalytic CATH Codes:
"Other" CATH Codes:
- 1.10.1610.10 - 5,6-Dimethylbenzimidazole Phosphoribosyltransferase; Chain: A; domain 1
Display structure information
Overall Comment: This enzyme [CobT] is one of the enzymes involved in adenosylcobalamin formation.
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Stepwise Description of the Reaction
|Step 1||The N1 of dimethylbenzimidazole initiates a nucleophilic attack on the C1 of the nicotinate D-ribonucleotide in a substitution reaction, eliminating nicotinate.|
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Catalytic Residues Involved
||Location of Function
- C. G. Cheong et al. (1999), Biochemistry, 38, 16125-16135. The three-dimensional structures of nicotinate mononucleotide:5,6- dimethylbenzimidazole phosphoribosyltransferase (CobT) from Salmonella typhimurium complexed with 5,6-dimethybenzimidazole and its reaction products determined to 1.9 A resolution.
Homologue information for M0079 (1d0s)
MACiE Homologues (within the PDB)
MACiE Homologues (within UniprotKB/SwissProt)
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