EC Number: 18.104.22.168 (A member of the Oxidoreductases, Acting on the CH-NH2 group of donors, With NAD+ or NADP+ as acceptor)
Enzyme Name: alanine dehydrogenase
Biological Species: Phormidium lapideum (Bacteria)
Catalytic Chain UniprotKB Accession Codes:
Representative PDB Code: 1pjb - L-ALANINE DEHYDROGENASE (Resolution = 2.10 Å).
Overall Comment: The role of Glu117 might be played by Asp269, the roles of His95 and Glu117 have been inferred from analogy to other L-2-hydroxyacid dehydrogenases as both residues are fully conserved in L-Ala DH sequences. Role of Tyr93 is tentatively assigned only. Biochemical data has suggested that the chemical mechanism proceeds through iminopyruvate and carbinolamine intermediates, with the stereochemistry of the carbinolamine thought to be that of L-amino and D-hydroxy groups .
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Stepwise Description of the Reaction
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Catalytic Residues Involved
Homologue information for M0067 (1pjb)
Entries with at least one Catalytic CATH code in common (different mechanisms):
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