Entry M0061 5.3.2.- 4-oxalocrotonate tautomerase
The N-terminal proline deprotonates the CH2 of the substrate, initiating double bond rearrangement and forming the enol form of the substrate.
Comment: Pro1 can function as a general base under physiological conditions because of its unusually low pKa of 6.4 .
Amino acids involved in the reaction step.
||Bonds Changed in Order
||Atom Types Involved
The C-C bond changes from a single to double bond
The C-O bond changes from a double to single bond
View similar reactions in MACiE.