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Entry M0060    3.5.99.6    glucosamine-6-phosphate deaminase

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Step 05

Asp72 deprotonates the newly added hydroxyl group, eliminating ammonia from the substrate.

GIF of Reaction Step M0060.stg05



Mechanisms

Bimolecular Elimination

Mechanism Components

Bond Cleavage
Bond Order Change
Bond Formation
Deamination
Intermediate Collapse
Intermediate Formation

Amino acids involved in the reaction step.

Amino Acid Location of Function Activity Function
His143 Side Chain spectator Hydrogen Bond Acceptor
Hydrogen Bond Donor
Asp72 Side Chain reactant Proton Acceptor
Hydrogen Bond Acceptor
Glu148 Side Chain spectator Hydrogen Bond Acceptor
Asp141 Side Chain spectator Hydrogen Bond Acceptor

Reactive Centre

Bonds Formed Bonds Cleaved Bonds Changed in Order Atom Types Involved
O-H
C-N
O-H
The C-O bond changes from a single to double bond
C
H
N
O

View similar reactions in MACiE.


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