Entry M0053 220.127.116.11 malate synthase
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The CoA intermediate rotates in the active site. The oxyanion collapses, initiating a nucleophilic attack on the carbonyl carbon of the oxo-acetic acid substrate in an addition reaction.
Comment: Before this catalytic step can occur the intermediate must rotate within the active site. The product of this step is Malyl-CoA.
Amino acids involved in the reaction step.
Metal Cofactors involved in Step 02
||Bonds Changed in Order
||Atom Types Involved
The C-O bond changes from a single to double bond
The C-C bond changes from a double to single bond
The C-O bond changes from a double to single bond
View similar reactions in MACiE.