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Entry M0052    4.1.2.13    fructose-bisphosphate aldolase (Class II)

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Step 03

Asp109 deprotonates water which deprotonates Glu182 in an inferred step.

This reaction step has been inferred

GIF of Reaction Step M0052.stg03


Comment: Distance between Glu182 and Asp109 is 6.95 Angstroms, thus return is depicted as a proton relay through water.



Mechanisms

Proton Transfer

Mechanism Components

Enzyme Regenerated
Bond Cleavage
Bond Formation
Proton Relay

Amino acids involved in the reaction step.

Amino Acid Location of Function Activity Function
Asn286 Side Chain spectator Not Active
Asp109 Side Chain reactant Proton Acceptor
Hydrogen Bond Acceptor
Glu182 Side Chain reactant Hydrogen Bond Donor
Proton Donor

Metal Cofactors involved in Step 03

Metal Type Metal Identity Chain Activity Function
zinc ZN 360 A spectator Not Active
sodium NA 364 A spectator Not Active

Reactive Centre

Bonds Formed Bonds Cleaved Bonds Changed in Order Atom Types Involved
O-H
O-H
O-H
O-H
None
H
O

View similar reactions in MACiE.


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