Entry M0052 188.8.131.52 fructose-bisphosphate aldolase (Class II)
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The oxyanion collapses, initiating nucleophilic addition of the intermediate to the glyceraldehyde-3-phosphate at the carbonyl carbon. The oxyanion formed deprotonates Asp109.
Rate Determining Step
Comment: Asn286 plays a role in restricting stereospecificity
Amino acids involved in the reaction step.
Metal Cofactors involved in Step 02
||Bonds Changed in Order
||Atom Types Involved
The C-O bond changes from a single to double bond
The C-C bond changes from a double to single bond
The C-O bond changes from a double to single bond
View similar reactions in MACiE.