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Entry M0050    4.1.1.23    orotidine-5'-phosphate decarboxylase

Previous Step

Step 02

Lys62 deprotonates water.

GIF of Reaction Step M0050.stg02


Comment: Harris et al [3] state that this reprotonation is from solvent.



Mechanisms

Proton Transfer

Mechanism Components

Bond Cleavage
Bond Formation
Enzyme Regenerated

Amino acids involved in the reaction step.

Amino Acid Location of Function Activity Function
Lys62 Side Chain reactant Proton Acceptor
Hydrogen Bond Acceptor
Hydrogen Bond Donor
Asp60 Side Chain spectator Hydrogen Bond Acceptor
Activator
Asp65B Side Chain spectator Hydrogen Bond Acceptor
Activator

Reactive Centre

Bonds Formed Bonds Cleaved Bonds Changed in Order Atom Types Involved
N-H
O-H
None
H
N
O

View similar reactions in MACiE.


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