Entry M0050 188.8.131.52 orotidine-5'-phosphate decarboxylase
The substrate undergoes decarboxylation. The substrate concomitantly deprotonates Lys62 forming UMP.
Rate Determining Step
Comment: The references for this reaction state that the mechanism is a SE2 however, we describe it as an E1cb and a proton transfer due to the nature of the substituting group, a proton.
Amino acids involved in the reaction step.
||Bonds Changed in Order
||Atom Types Involved
The C-O bond changes from a single to double bond
View similar reactions in MACiE.