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Entry M0049    4.1.1.22    histidine decarboxylase

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Step 04

The oxyanion formed initiates double bond rearrangement that results in the deprotonation of Glu197F at the CA position of the covalently attached histamine.

GIF of Reaction Step M0049.stg04



Mechanisms

Proton Transfer

Mechanism Components

Bond Cleavage
Bond Formation
Bond Order Change
Intermediate Formation

Amino acids involved in the reaction step.

Amino Acid Location of Function Activity Function
Tyr62 Side Chain spectator Hydrogen Bond Donor
Glu66 Side Chain spectator Hydrogen Bond Acceptor
Ser81E Main Chain C Terminus spectator Hydrogen Bond Acceptor
Glu197F Side Chain reactant Hydrogen Bond Donor
Proton Donor
Phe195F Main Chain Amide spectator Hydrogen Bond Donor
Electrostatic Stabiliser
Pvl82F Post-Translationally Modified Residue reactant Covalently Attached
Hydrogen Bond Acceptor
Two Electron Donor

Reactive Centre

Bonds Formed Bonds Cleaved Bonds Changed in Order Atom Types Involved
C-H
O-H
The C-N bond changes from a single to double bond
The C-O bond changes from a single to double bond
The C-C bond changes from a double to single bond
The C-N bond changes from a double to single bond
C
H
N
O

View similar reactions in MACiE.


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