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Entry M0037    1.14.99.1    prostaglandin-endoperoxide synthase

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Step 05

The carbon radical initiates a homolytic attack on a dioxygen molecule in an addition reaction.

GIF of Reaction Step M0037.stg05



Mechanisms

Radical Propagation
Bimolecular Homolytic Addition

Mechanism Components

Overall Reactant Used
Bond Formation
Bond Order Change
Intermediate Formation

Amino acids involved in the reaction step.

Amino Acid Location of Function Activity Function
Tyr385 Side Chain spectator Radical Stabiliser

Metal Cofactors involved in Step 05

Metal Type Metal Identity Chain Activity Function
iron HEM 601 A spectator Not Present

Reactive Centre

Bonds Formed Bonds Cleaved Bonds Changed in Order Atom Types Involved
C-O
None
The O-O bond changes from a double to single bond
C
O

View similar reactions in MACiE.


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