spacer

Entry M0037    1.14.99.1    prostaglandin-endoperoxide synthase

Previous Step     Next Step

Step 03

The porphyrin radical abstracts a hydrogen from Tyr385.

GIF of Reaction Step M0037.stg03


Comment: The mechanism of this step is unclear. Fe is from Haem. The haem is reduced to Fe(III) using an acid mechanism which is not well detailed in the references.



Mechanisms

Radical Propagation
Hydrogen Transfer

Mechanism Components

Bond Cleavage
Bond Formation
Intermediate Formation

Amino acids involved in the reaction step.

Amino Acid Location of Function Activity Function
Tyr385 Side Chain reactant Hydrogen Donor
Hydrogen Bond Donor

Metal Cofactors involved in Step 03

Metal Type Metal Identity Chain Activity Function
iron HEM 601 A spectator Not Active

Reactive Centre

Bonds Formed Bonds Cleaved Bonds Changed in Order Atom Types Involved
R-H
O-H
None
H
O
R

View similar reactions in MACiE.


spacer
spacer