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Overview for MACiE Entry M0023

Version history

General Information

EC Number: 2.1.1.20 (A member of the Transferases, Transferring one-carbon groups, Methyltransferases)

Enzyme Name: glycine N-methyltransferase

Biological Species: Rattus norvegicus (Rat)

Catalytic Chain UniprotKB Accession Codes:

  • P13255 - Glycine N-methyltransferase

Representative PDB Code: 1xva - METHYLTRANSFERASE (Resolution = 2.20 Å).

Catalytic CATH Codes:

  • Unassigned Domain

"Other" CATH Codes:

Display structure information

Overall Reaction:

Image of S-adenosyl-L-methionine

Image of glycine

right arrow

Image of proton

Image of sarcosine

Image of S-adenosyl-L-homocysteine

S-adenosyl-L-methionine
C00019
CHEBI:59789
glycine
C00037
CHEBI:32507
proton
C00080
CHEBI:24636
sarcosine
C00213
CHEBI:46842
S-adenosyl-L-homocysteine
C00021
CHEBI:57856

View similar reactions


Stepwise Description of the Reaction

Step 1Glu15B deprotonates the amine of the substrate glycine.
Step 2The amine of the substrate glycine initiates a nucleophilic attack on the methyl of the S-adenosyl-L-methionine in a substitution reaction.
Step 3Water deprotonates Glu15B in an inferred return step.

View similar reactions (composite manual annotation)


Catalytic Residues Involved

Type Number Chain Location of Function
Glu 15 B Side Chain

References

  1. Z. Fu et al. (1996), Biochemistry, 35, 11985-11993. Crystal structure of glycine N-methyltransferase from rat liver.
    Medline: 8810903

Homologue information for M0023 (1xva)

CSA Homologues

MACiE Homologues (within the PDB)

MACiE Homologues (within UniprotKB/SwissProt)


Links to this entry in other databases

Link to EC-PDB-SUM Link to PDB-SUM Link to RCSB PDB Link to PDBe Link to CSA
Link to MetaCyc Link to KEGG Link to BRENDA Link to ExplorENZ
Link to EzCatDB

GOA logo
folic acid binding (molecular function)
cytoplasm (cellular component)
methionine metabolic process (biological process)
glycine N-methyltransferase activity (molecular function)
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