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Entry M0002    3.5.2.6    beta-lactamase (Class A)

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Step 03

Ser130 deprotonates Lys73.

GIF of Reaction Step M0002.stg03



Mechanisms

Proton Transfer

Mechanism Components

Bond Cleavage
Bond Formation

Amino acids involved in the reaction step.

Amino Acid Location of Function Activity Function
Lys73 Side Chain reactant Proton Donor
Hydrogen Bond Donor
Ser130 Side Chain reactant Proton Acceptor
Hydrogen Bond Acceptor
Ser70A Side Chain spectator Covalently Attached
Hydrogen Bond Acceptor
Glu166 Side Chain spectator Hydrogen Bond Acceptor
Ser70A Main Chain Amide spectator Hydrogen Bond Donor
Ala237 Main Chain Amide spectator Hydrogen Bond Donor

Reactive Centre

Bonds Formed Bonds Cleaved Bonds Changed in Order Atom Types Involved
O-H
N-H
None
H
N
O

View similar reactions in MACiE.


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