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Structural Information for 1hfe

The following displays the crystal structure (as found in 1hfe, the primary PDB code for the entry) with each catalytic domain highlighted. The catalytic residues are also highlighed in teal and shown in wireframe depiction. Domains which are not classified as catalytic are shown in grey.

This enzyme has 4 catalytic sites (as determined by the Catalytic Site Atlas), only one of which is shown highlighed by CATH domain.
Site 1 covers chain L.
Site 2 covers chain M.
Site 3 covers chain L.
Site 4 covers chain M.


The Catalytic Domains:

  • 1hfeL03 (Code: 3.40.950.10) spans residues 149-200 and 290-380 in chain L (shown in blue)
  • 1hfeL01 (Code: 3.40.50.1780) spans residues 2-29 and 82-148 and 201-289 and 381-397 in chain L (shown in red)

The Catalytic Residues

The following shows the catalytic residues (the catalytic residue in focus is labelled in red) and the residues which are donating hydrogen bonds (labelled in blue) and accepting hydrogen bonds (labelled in green).

Glu 156 L

Residues Contacting Glu156L

B Factor
(normalised)
Relative Solvent Accessibility Number of H-Bond Donors Number of H-Bond Acceptors
17.5333
(0.7952)
1.3 3 1

Glu 159 L

Residues Contacting Glu159L

B Factor
(normalised)
Relative Solvent Accessibility Number of H-Bond Donors Number of H-Bond Acceptors
17.5522
(0.7963)
8.4 6 1

Cys 178 L

Residues Contacting Cys178L

B Factor
(normalised)
Relative Solvent Accessibility Number of H-Bond Donors Number of H-Bond Acceptors
11.94
(0.404)
8.5 2 2

Ser 198 L

Residues Contacting Ser198L

B Factor
(normalised)
Relative Solvent Accessibility Number of H-Bond Donors Number of H-Bond Acceptors
44.41
(0.4291)
0 3 2

Lys 237 L

Residues Contacting Lys237L

B Factor
(normalised)
Relative Solvent Accessibility Number of H-Bond Donors Number of H-Bond Acceptors
7.2133
(0.0161)
9.1 4 3

Glu 240 L

Residues Contacting Glu240L

B Factor
(normalised)
Relative Solvent Accessibility Number of H-Bond Donors Number of H-Bond Acceptors
9.7822
(0.1821)
2.2 6 1

Glu 245 L

Residues Contacting Glu245L

B Factor
(normalised)
Relative Solvent Accessibility Number of H-Bond Donors Number of H-Bond Acceptors
12.0155
(0.4127)
25.6 7 1

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