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SF4 610 A

Metal-MACiE entry for SF4 610 A

The iron-sulfur cluster is involved in electron relay.


Metal in MACiE Physiological Metal Site Type
iron iron Fe4S4

Resting State

nativeState of SF4 610 A
Download the coordinates file
Representative Structure
PDB code 2gmj
MACiE Metal Type
(Identity)
iron
(SF4610A)
PDB Metal Type (Identity) iron
(FE1,FE2,FE3,FE4612B)
Oxidation State 2
Coordination Geometry
(Number of ligands)
tetrahedral
(4)

First Coordination Sphere

Ligand Type Ligand (PDB) Ligand (MACiE) Catalytic Binding Mode Contacting Atoms
Amino Acid Residue CYS 528 BCYS 528 A No monodentate SG
Amino Acid Residue CYS 553 BCYS 553 A Yes monodentate SG
Note: This Cys is involved in activation
Amino Acid Residue CYS 556 BCYS 556 A Yes monodentate SG
Note: This Cys is involved in activation
Amino Acid Residue CYS 559 BCYS 559 A Yes monodentate SG
Note: This Cys is involved in activation
Cofactor SF4 612 B- No monodentate S1
Cofactor SF4 612 B- No monodentate S2
Cofactor SF4 612 B- No monodentate S3
Cofactor SF4 612 B- No monodentate S4

Step 01

Metal Functions

Electron Relay. Note: The iron-sulfur cluster tranfers the electron from the electron transfer flavoprotein to the FAD through interactions between the close proximity cabronyl of the metal ligand Cys556 and the carbonyl of Arg331

One Electron Donor. Note: It donates an electron to the substrate

One Electron Acceptor. Note: It receives an electron from the electron transfer flavoprotein

Structural Information


reagent of SF4 610 A
Download the coordinates file
Representative Structure
PDB code 2gmj
MACiE Metal Type
(Identity)
iron
(SF4610A)
PDB Metal Type (Identity) iron
(FE1,FE2,FE3,FE4612B)
Oxidation State 2
Coordination Geometry
(Number of ligands)
tetrahedral
(4)

First Coordination Sphere


Ligand Type Ligand (PDB) Ligand (MACiE) Catalytic Binding Mode Contacting Atoms
Amino Acid Residue CYS 528 BCYS 528 A No monodentate SG
Amino Acid Residue CYS 553 BCYS 553 A Yes monodentate SG
Note: This Cys is involved in activation
Amino Acid Residue CYS 556 BCYS 556 A Yes monodentate SG
Note: This Cys is involved in activation
Amino Acid Residue CYS 559 BCYS 559 A Yes monodentate SG
Note: This Cys is involved in activation
Cofactor SF4 612 B- No monodentate S1
Cofactor SF4 612 B- No monodentate S2
Cofactor SF4 612 B- No monodentate S3
Cofactor SF4 612 B- No monodentate S4




Right Arrow
MACiE Metal Type
(Identity)
iron
(SF4610A)
Oxidation State 2
Coordination Geometry
(Number of ligands)
tetrahedral
(4)

This step has no available structures in the PDB: all the coordinating information are derived from the reaction model in MACiE.


Step 02

Metal Functions

This metal is not active in this step.

Structural Information


MACiE Metal Type
(Identity)
iron
(SF4610A)
Oxidation State 2
Coordination Geometry
(Number of ligands)
tetrahedral
(4)

This step has no available structures in the PDB: all the coordinating information are derived from the reaction model in MACiE.





Right Arrow
MACiE Metal Type
(Identity)
iron
(SF4610A)
Oxidation State 2
Coordination Geometry
(Number of ligands)
tetrahedral
(4)

This step has no available structures in the PDB: all the coordinating information are derived from the reaction model in MACiE.


Step 03

Metal Functions

One Electron Acceptor. Note: It receives an electron from the electron transfer flavoprotein

Structural Information


MACiE Metal Type
(Identity)
iron
(SF4610A)
Oxidation State 2
Coordination Geometry
(Number of ligands)
tetrahedral
(4)

This step has no available structures in the PDB: all the coordinating information are derived from the reaction model in MACiE.





Right Arrow
MACiE Metal Type
(Identity)
iron
(SF4610A)
Oxidation State 1
Coordination Geometry
(Number of ligands)
tetrahedral
(4)

This step has no available structures in the PDB: all the coordinating information are derived from the reaction model in MACiE.


Step 04

Metal Functions

This metal is not active in this step.

Structural Information


reagent of SF4 610 A
Download the coordinates file
Representative Structure
PDB code 2gmh
MACiE Metal Type
(Identity)
iron
(SF4610A)
PDB Metal Type (Identity) iron
(FE1,FE2,FE3,FE4610A)
Oxidation State 1
Coordination Geometry
(Number of ligands)
tetrahedral
(4)

First Coordination Sphere


Ligand Type Ligand (PDB) Ligand (MACiE) Catalytic Binding Mode Contacting Atoms
Amino Acid Residue CYS 528 ACYS 528 A No monodentate SG
Amino Acid Residue CYS 553 ACYS 553 A Yes monodentate SG
Note: This Cys is involved in activation
Amino Acid Residue CYS 556 ACYS 556 A Yes monodentate SG
Note: This Cys is involved in activation
Amino Acid Residue CYS 559 ACYS 559 A Yes monodentate SG
Note: This Cys is involved in activation
Cofactor SF4 610 A- No monodentate S1
Cofactor SF4 610 A- No monodentate S2
Cofactor SF4 610 A- No monodentate S3
Cofactor SF4 610 A- No monodentate S4




Right Arrow
MACiE Metal Type
(Identity)
iron
(SF4610A)
Oxidation State 1
Coordination Geometry
(Number of ligands)
tetrahedral
(4)

This step has no available structures in the PDB: all the coordinating information are derived from the reaction model in MACiE.


Step 05

Metal Functions

One Electron Donor. Note: It donates an electron to the FAD. The centres are coupled by the interaction between the Cys556 carbonyl and Arg331

Structural Information


MACiE Metal Type
(Identity)
iron
(SF4610A)
Oxidation State 1
Coordination Geometry
(Number of ligands)
tetrahedral
(4)

This step has no available structures in the PDB: all the coordinating information are derived from the reaction model in MACiE.





Right Arrow
MACiE Metal Type
(Identity)
iron
(SF4610A)
Oxidation State 2
Coordination Geometry
(Number of ligands)
tetrahedral
(4)

This step has no available structures in the PDB: all the coordinating information are derived from the reaction model in MACiE.


Step 06

Metal Functions

This metal is not active in this step.

Structural Information


MACiE Metal Type
(Identity)
iron
(SF4610A)
Oxidation State 2
Coordination Geometry
(Number of ligands)
tetrahedral
(4)

This step has no available structures in the PDB: all the coordinating information are derived from the reaction model in MACiE.





Right Arrow
MACiE Metal Type
(Identity)
iron
(SF4610A)
Oxidation State 2
Coordination Geometry
(Number of ligands)
tetrahedral
(4)

This step has no available structures in the PDB: all the coordinating information are derived from the reaction model in MACiE.


Step 07

Metal Functions

This metal is not active in this step.

Structural Information


MACiE Metal Type
(Identity)
iron
(SF4610A)
Oxidation State 2
Coordination Geometry
(Number of ligands)
tetrahedral
(4)

This step has no available structures in the PDB: all the coordinating information are derived from the reaction model in MACiE.





Right Arrow
MACiE Metal Type
(Identity)
iron
(SF4610A)
Oxidation State 2
Coordination Geometry
(Number of ligands)
tetrahedral
(4)

This step has no available structures in the PDB: all the coordinating information are derived from the reaction model in MACiE.



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