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ZN 1224 A

Metal-MACiE entry for ZN 1224 A

The metal ion is directly involved in the reaction mechanism (substrate binding and activation).


Metal in MACiE Physiological Metal Site Type
zinc zinc mononuclear

Resting State

nativeState of ZN 1224 A
Download the coordinates file
Representative Structure
PDB code 1h1z
MACiE Metal Type
(Identity)
zinc
(ZN1224A)
PDB Metal Type (Identity) zinc
(ZN1224A)
Oxidation State 2
Coordination Geometry
(Number of ligands)
tetrahedral
(4)

First Coordination Sphere

Ligand Type Ligand (PDB) Ligand (MACiE) Catalytic Binding Mode Contacting Atoms
Amino Acid Residue HIS 36 AHIS 36 A No monodentate NE2
Amino Acid Residue ASP 38 AASP 38 A Yes monodentate OD1
Note: Asp38 is a proton relayer
Amino Acid Residue HIS 69 AHIS 69 A No monodentate ND1
Amino Acid Residue ASP 178 AASP 178 A Yes monodentate OD2

Step 01

Metal Functions

Activator

Increase Acidity

Substrate Binding

Structural Information


MACiE Metal Type
(Identity)
zinc
(ZN1224A)
Oxidation State 2
Coordination Geometry
(Number of ligands)
tetrahedral
(4)

This step has no available structures in the PDB: all the coordinating information are derived from the reaction model in MACiE.





Right Arrow
MACiE Metal Type
(Identity)
zinc
(ZN1224A)
Oxidation State 2
Coordination Geometry
(Number of ligands)
tetrahedral
(4)

This step has no available structures in the PDB: all the coordinating information are derived from the reaction model in MACiE.


Step 02

Metal Functions

Substrate Binding

Structural Information


MACiE Metal Type
(Identity)
zinc
(ZN1224A)
Oxidation State 2
Coordination Geometry
(Number of ligands)
tetrahedral
(4)

This step has no available structures in the PDB: all the coordinating information are derived from the reaction model in MACiE.





Right Arrow
MACiE Metal Type
(Identity)
zinc
(ZN1224A)
Oxidation State 2
Coordination Geometry
(Number of ligands)
tetrahedral
(4)

This step has no available structures in the PDB: all the coordinating information are derived from the reaction model in MACiE.


Step 03

Metal Functions

This metal is not active in this step.

Structural Information


MACiE Metal Type
(Identity)
zinc
(ZN1224A)
Oxidation State 2
Coordination Geometry
(Number of ligands)
tetrahedral
(4)

This step has no available structures in the PDB: all the coordinating information are derived from the reaction model in MACiE.





Right Arrow
MACiE Metal Type
(Identity)
zinc
(ZN1224A)
Oxidation State 2
Coordination Geometry
(Number of ligands)
tetrahedral
(4)

This step has no available structures in the PDB: all the coordinating information are derived from the reaction model in MACiE.



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