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MG 300 x

Metal-MACiE entry for MG 300 x

This enzyme uses a divalent cation such as Mg2+ or Mn2+ to perform the catalysis. It is not clear if the enzyme requires one or two metal ions (PMID15989951).


Metal in MACiE Physiological Metal Site Type
magnesium magnesium/manganese mononuclear

Resting State

nativeState of MG 300 x
Download the coordinates file
Representative Structure
PDB code 1rdd
MACiE Metal Type
(Identity)
magnesium
(MG300x)
PDB Metal Type (Identity) magnesium
(MG300_)
Oxidation State 2
Coordination Geometry
(Number of ligands)
unknownGeometry
(3)

First Coordination Sphere

Ligand Type Ligand (PDB) Ligand (MACiE) Catalytic Binding Mode Contacting Atoms
Amino Acid Residue ASP 10 ASP 10 No monodentate OD1
Amino Acid Residue GLY 11 GLY 11 No monodentate O
Amino Acid Residue GLU 48 GLU 48 No monodentate OE2

Step 01

Metal Functions

Substrate Binding

Electrostatic Stabiliser

Increase Electrophilicity. Note: it increases electrophilicity of substrate

Activator. Note: it polarizes the P-O bond

Structural Information


reagent of MG 300 x
Download the coordinates file
Representative Structure
PDB code 1zbi
MACiE Metal Type
(Identity)
magnesium
(MG300x)
PDB Metal Type (Identity) magnesium
(MG301_)
Oxidation State 2
Coordination Geometry
(Number of ligands)
unknownGeometry
(6)

First Coordination Sphere


Ligand Type Ligand (PDB) Ligand (MACiE) Catalytic Binding Mode Contacting Atoms
Amino Acid Residue ASP 71 A- No monodentate OD1
Amino Acid Residue GLU 109 AGLU 48 No bidentate OE1,OE2
Amino Acid Residue ASN 132 AASP 70 No monodentate OD1
Reactive Species U 10 C- No monodentate O1P
Water HOH 119 - No monodentate O




Right Arrow
MACiE Metal Type
(Identity)
magnesium
(MG300x)
Oxidation State 2
Coordination Geometry
(Number of ligands)
unknownGeometry
(9999)

This step has no available structures in the PDB: all the coordinating information are derived from the reaction model in MACiE.


Step 02

Metal Functions

This metal is not active in this step.

Structural Information


MACiE Metal Type
(Identity)
magnesium
(MG300x)
Oxidation State 2
Coordination Geometry
(Number of ligands)
unknownGeometry
(9999)

This is an inferred step.

This step has no available structures in the PDB: all the coordinating information are derived from the reaction model in MACiE.





Right Arrow
MACiE Metal Type
(Identity)
magnesium
(MG300x)
Oxidation State 2
Coordination Geometry
(Number of ligands)
unknownGeometry
(9999)

This step has no available structures in the PDB: all the coordinating information are derived from the reaction model in MACiE.



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