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FCO 537 L

Metal-MACiE entry for FCO 537 L

The enzyme is a heterodimeric protein consisting of small and large subunits. The large subunit provides the catalytic site which is dinuclear, containing both Ni and Fe (PMID11703120).


Metal in MACiE Physiological Metal Site Type
iron iron dinuclear

Resting State

nativeState of FCO 537 L
Download the coordinates file
Representative Structure
PDB code 2frv
MACiE Metal Type
(Identity)
iron
(FCO537L)
PDB Metal Type (Identity) iron
(FE537L)
Oxidation State 2
Coordination Geometry
(Number of ligands)
octahedral
(6)

The coordination geometry of the Fe is a slightly distorted octahedron, with three bridging ligands between Ni and Fe (two S of Cys residues and one S or O atom) and three terminal ligands that do not derived from the polypeptide chain.

There is a lack of information on the resting state of the enzyme and the oxidation states of the resting metals. This is an oxidized structure.


First Coordination Sphere

Ligand Type Ligand (PDB) Ligand (MACiE) Catalytic Binding Mode Contacting Atoms
Amino Acid Residue CYS 68 LCYS 68 L No monodentate SG
Amino Acid Residue CYS 533 LCYS 533 L No monodentate SG
Cofactor FCO 537 LFCO 537 L No monodentate C1
Cofactor FCO 537 LFCO 537 L No monodentate C2
Cofactor O 539 LO 539 L No monodentate O
Note: It is an oxygen atom.
Cofactor FCO 537 LFCO 537 L No monodentate C3

Step 01

Metal Functions

This metal is not active in this step.

Structural Information


MACiE Metal Type
(Identity)
iron
(FCO537L)
Oxidation State 2
Coordination Geometry
(Number of ligands)
octahedral
(6)

This step has no available structures in the PDB: all the coordinating information are derived from the reaction model in MACiE.





Right Arrow
MACiE Metal Type
(Identity)
iron
(FCO537L)
Oxidation State 2
Coordination Geometry
(Number of ligands)
octahedral
(6)

This step has no available structures in the PDB: all the coordinating information are derived from the reaction model in MACiE.


Step 02

Metal Functions

This metal is not active in this step.

Structural Information


MACiE Metal Type
(Identity)
iron
(FCO537L)
Oxidation State 2
Coordination Geometry
(Number of ligands)
octahedral
(6)

This step has no available structures in the PDB: all the coordinating information are derived from the reaction model in MACiE.





Right Arrow
MACiE Metal Type
(Identity)
iron
(FCO537L)
Oxidation State 2
Coordination Geometry
(Number of ligands)
octahedral
(6)

This step has no available structures in the PDB: all the coordinating information are derived from the reaction model in MACiE.


Step 03

Metal Functions

Substrate Binding

Structural Information


MACiE Metal Type
(Identity)
iron
(FCO537L)
Oxidation State 2
Coordination Geometry
(Number of ligands)
octahedral
(6)

This step has no available structures in the PDB: all the coordinating information are derived from the reaction model in MACiE.





Right Arrow
MACiE Metal Type
(Identity)
iron
(FCO537L)
Oxidation State 2
Coordination Geometry
(Number of ligands)
octahedral
(6)

This step has no available structures in the PDB: all the coordinating information are derived from the reaction model in MACiE.


Step 04

Metal Functions

This metal is not active in this step.

Structural Information


MACiE Metal Type
(Identity)
iron
(FCO537L)
Oxidation State 2
Coordination Geometry
(Number of ligands)
octahedral
(6)

This step has no available structures in the PDB: all the coordinating information are derived from the reaction model in MACiE.





Right Arrow
MACiE Metal Type
(Identity)
iron
(FCO537L)
Oxidation State 2
Coordination Geometry
(Number of ligands)
octahedral
(6)

This step has no available structures in the PDB: all the coordinating information are derived from the reaction model in MACiE.


Step 05

Metal Functions

This metal is not active in this step.

Structural Information


MACiE Metal Type
(Identity)
iron
(FCO537L)
Oxidation State 2
Coordination Geometry
(Number of ligands)
octahedral
(6)

This step has no available structures in the PDB: all the coordinating information are derived from the reaction model in MACiE.





Right Arrow
MACiE Metal Type
(Identity)
iron
(FCO537L)
Oxidation State 2
Coordination Geometry
(Number of ligands)
octahedral
(6)

This step has no available structures in the PDB: all the coordinating information are derived from the reaction model in MACiE.



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