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F3S 266 S

Metal-MACiE entry for F3S 266 S

The enzyme is a heterodimeric protein consisting of small and large subunits. The small subunit contains three iron-sulphur clusters. These clusters were called proximal, median and distal according to their distance from the catalytic site and were proposed to provide an electron transfer pathway from the catalytic site to cytochrome C3. This is the median FeS (PMID7854413).


Metal in MACiE Physiological Metal Site Type
iron iron Fe3S4

Resting State

nativeState of F3S 266 S
Download the coordinates file
Representative Structure
PDB code 2frv
MACiE Metal Type
(Identity)
iron
(F3S266S)
PDB Metal Type (Identity) iron
(FE1,FE2,FE3,FE4266S)
Oxidation State 9999
Coordination Geometry
(Number of ligands)
tetrahedral
(4)

There is a lack of information on the resting state of the enzyme and the oxidation states of the resting metals. This is an oxidized structure.


First Coordination Sphere

Ligand Type Ligand (PDB) Ligand (MACiE) Catalytic Binding Mode Contacting Atoms
Amino Acid Residue CYS 228 SCYS 228 S No monodentate SG
Note: It coordinates FE2
Amino Acid Residue CYS 246 SCYS 246 S No monodentate SG
Note: It coordinates FE3
Amino Acid Residue CYS 249 SCYS 249 S No monodentate SG
Note: It coordinates FE1
Cofactor F3S 266 SF3S 266 S No monodentate S1
Cofactor F3S 266 SF3S 266 S No monodentate S2
Cofactor F3S 266 SF3S 266 S No monodentate S3
Cofactor F3S 266 SF3S 266 S No monodentate S4

Step 01

Metal Functions

One Electron Acceptor

One Electron Donor

Electron Relay. Note: It relies an electron from FS4_267 to FS4_265.

Structural Information


MACiE Metal Type
(Identity)
iron
(F3S266S)
Oxidation State 3
Coordination Geometry
(Number of ligands)
tetrahedral
(4)

This step has no available structures in the PDB: all the coordinating information are derived from the reaction model in MACiE.





Right Arrow
MACiE Metal Type
(Identity)
iron
(F3S266S)
Oxidation State 3
Coordination Geometry
(Number of ligands)
tetrahedral
(4)

This step has no available structures in the PDB: all the coordinating information are derived from the reaction model in MACiE.


Step 02

Metal Functions

This metal is not active in this step.

Structural Information


MACiE Metal Type
(Identity)
iron
(F3S266S)
Oxidation State 2
Coordination Geometry
(Number of ligands)
tetrahedral
(4)

This step has no available structures in the PDB: all the coordinating information are derived from the reaction model in MACiE.





Right Arrow
MACiE Metal Type
(Identity)
iron
(F3S266S)
Oxidation State 2
Coordination Geometry
(Number of ligands)
tetrahedral
(4)

This step has no available structures in the PDB: all the coordinating information are derived from the reaction model in MACiE.


Step 03

Metal Functions

This metal is not active in this step.

Structural Information


MACiE Metal Type
(Identity)
iron
(F3S266S)
Oxidation State 2
Coordination Geometry
(Number of ligands)
tetrahedral
(4)

This step has no available structures in the PDB: all the coordinating information are derived from the reaction model in MACiE.





Right Arrow
MACiE Metal Type
(Identity)
iron
(F3S266S)
Oxidation State 2
Coordination Geometry
(Number of ligands)
tetrahedral
(4)

This step has no available structures in the PDB: all the coordinating information are derived from the reaction model in MACiE.


Step 04

Metal Functions

This metal is not active in this step.

Structural Information


MACiE Metal Type
(Identity)
iron
(F3S266S)
Oxidation State 2
Coordination Geometry
(Number of ligands)
tetrahedral
(4)

This step has no available structures in the PDB: all the coordinating information are derived from the reaction model in MACiE.





Right Arrow
MACiE Metal Type
(Identity)
iron
(F3S266S)
Oxidation State 2
Coordination Geometry
(Number of ligands)
tetrahedral
(4)

This step has no available structures in the PDB: all the coordinating information are derived from the reaction model in MACiE.


Step 05

Metal Functions

One Electron Donor

One Electron Acceptor

Electron Relay. Note: It relies an electron from FS4_267 to FS4_265

Structural Information


MACiE Metal Type
(Identity)
iron
(F3S266S)
Oxidation State 2
Coordination Geometry
(Number of ligands)
tetrahedral
(4)

This step has no available structures in the PDB: all the coordinating information are derived from the reaction model in MACiE.





Right Arrow
MACiE Metal Type
(Identity)
iron
(F3S266S)
Oxidation State 2
Coordination Geometry
(Number of ligands)
tetrahedral
(4)

This step has no available structures in the PDB: all the coordinating information are derived from the reaction model in MACiE.



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