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C2O 500 A

Metal-MACiE entry for C2O 500 A

The dinuclear copper site is directly involved in the catalytic reaction (substrate binding and activation, redox center...) (PMID15185133).


Metal in MACiE Physiological Metal Site Type
copper copper dinuclear

Resting State

nativeState of C2O 500 A
Download the coordinates file
Representative Structure
PDB code 1bt1
MACiE Metal Type
(Identity)
copper
(C2O500A)
PDB Metal Type (Identity) copper
(CU2500A)
Oxidation State 1
Coordination Geometry
(Number of ligands)
trigonalPyramidal
(4)

In the native state of the enzyme the dinuclear copper center is oxidised (PMID9846879).


First Coordination Sphere

Ligand Type Ligand (PDB) Ligand (MACiE) Catalytic Binding Mode Contacting Atoms
Amino Acid Residue HIS 88 AHIS 88 A No monodentate NE2
Amino Acid Residue HIS 109 AHIS 109 A No monodentate NE2
Amino Acid Residue HIS 118 AHIS 118 A No monodentate NE2
Water C2O 500 B- No monodentate O1
Note: It is an hydroxide ion.

Step 01

Metal Functions

Substrate Binding

Activator. Note: It activates both the substrates.

Structural Information


MACiE Metal Type
(Identity)
copper
(C2O500A)
Oxidation State 1
Coordination Geometry
(Number of ligands)
trigonalPyramidal
(4)

This step has no available structures in the PDB: all the coordinating information are derived from the reaction model in MACiE.





Right Arrow
MACiE Metal Type
(Identity)
copper
(C2O500A)
Oxidation State 1
Coordination Geometry
(Number of ligands)
trigonalPyramidal
(4)

This step has no available structures in the PDB: all the coordinating information are derived from the reaction model in MACiE.


Step 02

Metal Functions

Substrate Binding

Structural Information


MACiE Metal Type
(Identity)
copper
(C2O500A)
Oxidation State 1
Coordination Geometry
(Number of ligands)
trigonalPyramidal
(4)

This step has no available structures in the PDB: all the coordinating information are derived from the reaction model in MACiE.





Right Arrow
MACiE Metal Type
(Identity)
copper
(C2O500A)
Oxidation State 1
Coordination Geometry
(Number of ligands)
trigonalPyramidal
(4)

This step has no available structures in the PDB: all the coordinating information are derived from the reaction model in MACiE.


Step 03

Metal Functions

Substrate Binding

Structural Information


MACiE Metal Type
(Identity)
copper
(C2O500A)
Oxidation State 1
Coordination Geometry
(Number of ligands)
trigonalPyramidal
(4)

This step has no available structures in the PDB: all the coordinating information are derived from the reaction model in MACiE.





Right Arrow
MACiE Metal Type
(Identity)
copper
(C2O500A)
Oxidation State 1
Coordination Geometry
(Number of ligands)
trigonalPyramidal
(4)

This step has no available structures in the PDB: all the coordinating information are derived from the reaction model in MACiE.


Step 04

Metal Functions

One Electron Donor

Structural Information


MACiE Metal Type
(Identity)
copper
(C2O500A)
Oxidation State 1
Coordination Geometry
(Number of ligands)
trigonalBipyramidal
(4)

This step has no available structures in the PDB: all the coordinating information are derived from the reaction model in MACiE.





Right Arrow
MACiE Metal Type
(Identity)
copper
(C2O500A)
Oxidation State 2
Coordination Geometry
(Number of ligands)
trigonalPyramidal
(4)

This step has no available structures in the PDB: all the coordinating information are derived from the reaction model in MACiE.


Step 05

Metal Functions

One Electron Acceptor

Structural Information


MACiE Metal Type
(Identity)
copper
(C2O500A)
Oxidation State 2
Coordination Geometry
(Number of ligands)
trigonalPyramidal
(4)

This step has no available structures in the PDB: all the coordinating information are derived from the reaction model in MACiE.





Right Arrow
MACiE Metal Type
(Identity)
copper
(C2O500A)
Oxidation State 1
Coordination Geometry
(Number of ligands)
trigonalPyramidal
(4)

This step has no available structures in the PDB: all the coordinating information are derived from the reaction model in MACiE.



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