CATALYTIC METAL(S)

Metal/Site Information
Residue in MACiE* Atom in MACiE* Residue Type in MACiE Physiological
Metal
Site
Type
Function(s)
ZN 1001 AZN zinc divalent cation mononuclear Coordinates substrate
Increases nucleophilicity
Electrostatic stabiliser
Increases acidity
ZN 1002 AZN zinc divalent cation mononuclear Coordinates substrate
Electrostatic stabiliser
Increases electrophilicity

*It refers to the MACiE reference pdb: 1yt3

Metal/s Properties in Resting State
ZN 1001 A
Oxidation State 2
Coordination Geometry tetrahedral
Coordination Number 4
Notes -
ZN 1002 A
Oxidation State 2
Coordination Geometry octahedral
Coordination Number 6
Notes -


References
-Steitz TA, Steitz JA
A general two-metal-ion mechanism for catalytic RNA.
Proc Natl Acad Sci U S A. 1993 Jul 15;90(14):6498-502.(MEDLINE:8341661)