CATALYTIC METAL(S)

Metal/Site Information
Residue in MACiE* Atom in MACiE* Residue Type in MACiE Physiological
Metal
Site
Type
Function(s)
ZN 262 _ZN zinc zinc mononuclear Increases nucleophilicity
Increases acidity

*It refers to the MACiE reference pdb: 1ca2

Metal/s Properties in Resting State
ZN 262 _
Oxidation State 2
Coordination Geometry tetrahedral
Coordination Number 4
Notes -


References
-Supuran CT, Scozzafava A, Casini A
Carbonic anhydrase inhibitors.
Med Res Rev. 2003 Mar;23(2):146-89.(MEDLINE:12500287)
-Fisher Z, Hernandez Prada JA, Tu C, Duda D, Yoshioka C, An H, Govindasamy L, Silverman DN, McKenna R
Structural and kinetic characterization of active-site histidine as a proton shuttle in catalysis by human carbonic anhydrase II.
Biochemistry. 2005 Feb 1;44(4):1097-105.(MEDLINE:15667203)