CATALYTIC METAL(S)

Metal/Site Information
Residue in MACiE* Atom in MACiE* Residue Type in MACiE Physiological
Metal
Site
Type
Function(s)
ZN 800 xZN zinc divalent cation dinuclear Coordinates substrate
Increases nucleophilicity
Increases electrophilicity
ZN 801 xZN zinc divalent cation dinuclear Coordinates substrate
Increases nucleophilicity

*It refers to the MACiE reference pdb: 1onw

Metal/s Properties in Resting State
ZN 800 x
Oxidation State 2
Coordination Geometry trigonalBipyramidal
Coordination Number 5
Notes -
ZN 801 x
Oxidation State 2
Coordination Geometry tetrahedral
Coordination Number 4
Notes -


References
-Martí-Arbona R, Fresquet V, Thoden JB, Davis ML, Holden HM, Raushel FM
Mechanism of the reaction catalyzed by isoaspartyl dipeptidase from Escherichia coli.
Biochemistry. 2005 May 17;44(19):7115-24.(MEDLINE:15882050)