The enzyme catalyzes the reduction of arsenate (HAsO) to arsenite (H3AsO3) and participates in the arsenic detoxification systems of prokaryotes and eukaryotes PMID12072565. The enzyme from Staphylococcus aureus binds a potassium ion that is involved in stabilizing the structure of the active site and increases the activity of the enzyme PMID16797027.
|Residue in MACiE*||Atom in MACiE*||Residue Type in MACiE||Physiological
|K 133 _||K||potassium||potassium||mononuclear|| Structural (in the active site)|
*It refers to the MACiE reference pdb: 1ljl
|Metal/s Properties in Resting State|
|K 133 _||Resting state enzyme (1ljl)|
|-Roos G, Buts L, Van Belle K, Brosens E, Geerlings P, Loris R, Wyns L, Messens J|
Interplay between ion binding and catalysis in the thioredoxin-coupled arsenate reductase family.
J Mol Biol. 2006 Jul 21;360(4):826-38. Epub 2006 Jun 6.(MEDLINE:16797027)