The enzyme catalyzes the formation of two molecules of l-glutamate from 2-oxoglutarate and l-glutamine via intramolecular channeling of ammonia. It uses one FMN cofactor and one 3Fe-4S cluster as prosthetic groups (PMID11967268).
|Residue in MACiE*||Atom in MACiE*||Residue Type in MACiE||Physiological
|F3S 2509 A||FE1,FE2,FE3||iron||iron||Fe3S4|| Electron relay|
*It refers to the MACiE reference pdb: 1ofd
|Metal/s Properties in Resting State|
|F3S 2509 A||Resting state enzyme (1lm1)|
|Notes||The coordination number and the geometry refer to each single iron in the iron-sulfur cluster whereas the oxidation state is the formal oxidation state of the whole cluster.|
|N.B.The coordination number and the geometry refer to each single iron in the iron-sulfur cluster whereas the oxidation state is the formal oxidation state of the whole cluster.|
|-van den Heuvel RH, Curti B, Vanoni MA, Mattevi A|
Glutamate synthase: a fascinating pathway from L-glutamine to L-glutamate.
Cell Mol Life Sci. 2004 Mar;61(6):669-81.(MEDLINE:15052410)
|-van den Heuvel RH, Ferrari D, Bossi RT, Ravasio S, Curti B, Vanoni MA, Florencio FJ, Mattevi A|
Structural studies on the synchronization of catalytic centers in glutamate synthase.
J Biol Chem. 2002 Jul 5;277(27):24579-83. Epub 2002 Apr 19.(MEDLINE:11967268)