The enzyme catalyzes the condensation of IMP with aspartate to form adenylosuccinate in the purine salvage pathway, in a reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+ (PMID14729341).
|Residue in MACiE*||Atom in MACiE*||Residue Type in MACiE||Physiological
|MG 435 A||MG||magnesium||magnesium||mononuclear|| Coordinates substrate|
*It refers to the MACiE reference pdb: 1gim
|Metal/s Properties in Resting State|
|MG 435 A||Resting state enzyme (-)|
|-Poland BW, Bruns C, Fromm HJ, Honzatko RB|
Entrapment of 6-thiophosphoryl-IMP in the active site of crystalline adenylosuccinate synthetase from Escherichia coli.
J Biol Chem. 1997 Jun 13;272(24):15200-5.(MEDLINE:9182542)
|- Some information have been also deduced from the MACiE mechanism model|