CATALYTIC METAL(S)

Metal/Site Information
Residue in MACiE* Atom in MACiE* Residue Type in MACiE Physiological
Metal
Site
Type
Function(s)
ZN 301 xZN zinc zinc/manganese trinuclear Electrostatic stabiliser
Increases nucleophilicity
Coordinates substrate
Increases electrophilicity
ZN 302 xZN zinc zinc/manganese trinuclear Electrostatic stabiliser
Coordinates substrate
Increases electrophilicity
ZN 303 xZN zinc zinc/manganese trinuclear Electrostatic stabiliser
Increases nucleophilicity
Coordinates substrate
Increases electrophilicity

*It refers to the MACiE reference pdb: 1qum

Metal/s Properties in Resting State
ZN 301 x
Oxidation State 2
Coordination Geometry tetrahedral
Coordination Number 4
Notes -
ZN 302 x
Oxidation State 2
Coordination Geometry trigonalBipyramidal
Coordination Number 6
Notes -
ZN 303 x
Oxidation State 2
Coordination Geometry trigonalBipyramidal
Coordination Number 5
Notes -


References
-Hosfield DJ, Guan Y, Haas BJ, Cunningham RP, Tainer JA
Structure of the DNA repair enzyme endonuclease IV and its DNA complex: double-nucleotide flipping at abasic sites and three-metal-ion catalysis.
Cell. 1999 Aug 6;98(3):397-408.(MEDLINE:10458614)