MACiE, which stands for Mechanism, Annotation and Classification in Enzymes, is a collaborative project between the Thornton Group at the European Bioinformatics Institute and the Mitchell Group at the University of St Andrews (initially within the Unilever Centre for Molecular Informatics part of the University of Cambridge). We have also extended to collaboration to include the Bertini Group at the Magnetic Resonance Center (CERM) in Florence (Italy). This aspect of the collaboration incorporates the expertise of CERM with metalloproteins and we have developed Metal MACiE, a database of catalytic metal ions, with a view to understanding the functions of the roles and activity of catalytic metals in enzymes.
The current version of MACiE (Version 3.0) contains 335 fully annotated enzyme reaction mechanisms, which comprise 321 EC numbers (182 EC sub-subclasses) and 372 distinct CATH codes.
If using MACiE, please cite: MACiE: exploring the diversity of biochemical reactions. G. L. Holliday, C. Andreini, J. D. Fischer, S. A. Rahman, D. E. Almonacid, S. T. Williams and W. R. Pearson. Nucleic Acids Research, 40, D783-D789, 2012. Medline ID: 22058127. For a full list of publications relating to the MACiE Database, please see here.
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Last Updated: 6th September 2011
MACiE has been funded by: